Discontinuation of lithium therapy may be followed by a number of reactions.
Reaction After Discontinuation
bipolar, depression or other psychiatric disease
relapse risk starting 2-3 weeks after discontinuation
concurrent therapy with chlorpromazine
prolonged QTc and ventricular fibrillation if chlorpromazine dose is not reduced
adenylate cyclase system may be supersensitive to stimuli (? transient bleeding disorder)
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Purpose: To evaluate a patient following discontinuation of chronic lithium therapy.
Specialty: Psychiatry, Pharmacology, clinical
Objective: adverse effects
ICD-10: F19.9, F20, F21, F30, F31, F32, F33, G44.0, T43.0,