Discontinuation of lithium therapy may be followed by a number of reactions.


Reaction After Discontinuation

bipolar, depression or other psychiatric disease

relapse risk starting 2-3 weeks after discontinuation

concurrent therapy with chlorpromazine

prolonged QTc and ventricular fibrillation if chlorpromazine dose is not reduced

platelet function

adenylate cyclase system may be supersensitive to stimuli (? transient bleeding disorder)


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