Liu et al reported the LIP score to screen a patient for sepsis. This can help to identify a patient who may benefit from more aggressive management. The authors are from Chongqing Medical University, Fudan University, and affiliated hospitals.
LIP = lymphocyte count, INR, procalcitonin
Patient selection: adult with suspected acute infection
Parameters:
(1) absolute lymphocyte count in 10^9/L
(2) international normalized ratio (INR)
(3) serum procalcitonin in ng/mL
Parameter
Finding
Points
lymphocyte count
> 1 * 10^9/L
0
0.7 - 1.0 * 10^9/L
1
< 0.7 * 10^9/L
2
INR
< 1.2
0
1.2 - 1.4
1
> 1.4
2
procalcitonin
< 0.5 ng/mL
0
0.5 - 2.0 ng/mL
1
> 2.0 ng/mL
2
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 6
• A score >= 3 indicates early sepsis.
Performance:
• The area under the ROC curve is reported as 0.97.
• The negative predictive value is 0.93.
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