Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) is a disorder seen in the elderly that may closely resemble Alzheimer's disease.
Clinical features:
(1) older adult, often > 80 years of age
(2) amnestic dementia syndrome that resembles Alzheimer's disease
(3) variable agitation/aggression
(4) disability in activities of daily living
Neuropathologic features:
(1) TDP-43 proteinopathy which can be detected by immunohistochemistry
(2) variable hippocampal sclerosis
(3) variable amyloid-beta plaques and tauopathy
(4) variable atrophy in the medial temporal lobes, frontal cortex and other brain regions
Stages based on the extent of TDP-43 pathology:
(1) Stage 1: amygdala only
(2) Stage 2: plus hippocampus
(3) Stage 3: plus middle frontal gyrus
