Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) is a disorder seen in the elderly that may closely resemble Alzheimer's disease.

Clinical features:

(1) older adult, often > 80 years of age

(2) amnestic dementia syndrome that resembles Alzheimer's disease

(3) variable agitation/aggression

(4) disability in activities of daily living


Neuropathologic features:

(1) TDP-43 proteinopathy which can be detected by immunohistochemistry

(2) variable hippocampal sclerosis

(3) variable amyloid-beta plaques and tauopathy

(4) variable atrophy in the medial temporal lobes, frontal cortex and other brain regions


Stages based on the extent of TDP-43 pathology:

(1) Stage 1: amygdala only

(2) Stage 2: plus hippocampus

(3) Stage 3: plus middle frontal gyrus

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