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Li-Mantel Method for Correction of Truncate Ascertainment in Families with Two Offspring

Specialty:

Genetics

Objective:

ICD-10:

Description:

In truncate ascertainment all of the families in a population with at least one affected offspring are identified. Li and Mantel proposed a method to correct for the bias of this manner of ascertainment. The following assumes that the identified families have 2 offspring, at least one of which is affected by the genetic condition of interest.

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