Leptocytes are an uncommon finding in peripheral blood smears.

Features of a leptocyte:

(1) flat, thin and wafer-like

(2) hypochromic with a large area of central pallor and a thin rim of hemoglobin at the periphery


Conditions associated with leptocytes:

(1) obstructive liver disease

(2) thalassemia (hemoglobin H)

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