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LENT Score for Prognosis of Patient with Malignant Pleural Effusion

Purpose: To evaluate a patient with a malignant pleural effusion using the LENT score of Clive et al.

Description

Clive et reported the LENT score to aid in predicting the prognosis for a patient with a malignant pleural effusion. The authors are from the University of Bristol, Southmead Hospital, Queen Mary University of London. Antonie van Leeuwenhoek Hospital, Sir Charles Gardner Hospital (Perth) and the University of Western Australia.


Patient selection: malignant pleural effusion

 

Outcome: cumulative survival

 

Acronym:

(1) L: pleural fluid LDH

(2) E: ECOG performance score

(3) N: neutrophil-to-lymphocyte ratio (NLR) in peripheral blood

(4) T: tumor type

 

Parameter

Finding

Points

pleural fluid LDH

< 1,500 IU/L

0

 

>= 1,500 IU/L

1

ECOG PS

0

0

 

1

1

 

2

2

 

3 or 4

3

neutrophil to lymphocyte ratio

< 9

0

 

>= 9

1

tumor type

low risk (mesothelioma, hematologic malignancy)

0

 

moderate risk (breast, gynecologic, renal cell)

1

 

high risk (lung, other tumor types)

2

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 7

• The higher the score the greater the risk.

 

Score

Risk Group

Median Survival

0 or 1

low

319 days

2 to 4

moderate

130 days

5 to 7

high

44 days

 

Performance:

• The area under the ROC curve was 0.78 at 1 month and 0.76 at 3 months.


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Specialty

Objective

ICD-10