The Leaky Gut Syndrome refers to increased permeability of the gut mucosa allowing absorption of luminal contents.
Evidence for a leaky gut:
(1) increased absorption of inert and nonmetabolized compounds (mannitol, rhamnose, lactulose, chromium-51-EDTA)
(2) elevated fecal calprotectin
(3) bacteremia with gut bacteria
(4) endotoxemia
Conditions associated with a leaky gut:
(1) inflammatory bowel disease
(2) celiac disease
(3) chronic alcohol consumption and cirrhosis
(4) NSAIDs
(5) chronic kidney disease with uremia
(6) gastrointestinal infection
(7) SLE
(8) burns
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Specialty: Gastroenterology
