Hanafy et al reported a score for ulcerative colitis based on laboratory findings. This offers a noninvasive means of identifying a patient with active ulcerative colitis and to monitor response to therapy. The authors are from Zagazig University in Egypt.
Patient selection: ulcerative colitis
Parameters:
(1) mean platelet volume (MPV) in femtoliters
(2) neutrophil to lymphocyte ratio (NLR)
(3) ESR in mm at 1 hour
(4) fecal lactoferrin in micrograms per mL
(5) C-reactive protein (CRP) in mg/L
(6) stool WBC per high power field (hpf)
(7) stool RBC per hpf
Parameter
Finding
Points
MPV
>= 8.8 fL
0
< 8.8 fL
1
NLR
<= 2.35
0
> 2.35
1
ESR
<= 29.5 mm in first hour
0
> 29.5 mm in first hour
1
fecal lactoferrin
<= 148.5 µg/mL
0
> 148.5 µg/mL
1
CRP
<= 3.85 mg/L
0
> 3.85 mg/L
1
stool WBC
<= 9 per hpf
0
> 9 per hpf
1
stool RBC
<= 6 per hpf
0
> 6 per hpf
1
score =
= SUM(points for all 7 parameters)
Interpretation:
• minimum score: 0
• maximum score: 7
• A score >= 5 identifies 94% of patients with active ulcerative colitis.
Performance:
• The area under the ROC curve is 0.92.
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