Zhou et al reported an index based on laboratory tests to identify a patient with severe depression. The authors are from Sir Run Run Shaw Hospital, Zhejiang University, and Hangzhou Normal University in China.
Patient selection: depressive disorder
Parameters:
(1) ratio of CD4+ to CD8+ T cells
(2) serum albumin concentration in g/L
(3) percent monocytes in the differential count
joint index =
= 8.739 - (3.959 * (T cell ratio)) - (0.175 * (albumin)) + (0.522 * (percent monocytes))
Joint Index
Severe Depression
> -1.2
higher probability
< -1.2
less likely
Performance:
• The area under the ROC curve was 0.85 for the derivation and 0.75 for the validation cohorts.
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Specialty: Psychiatry
