Laboratory Findings That May Indicate the Presence of an Organic Acidemia/Aciduria

A patient with an organic academia (organic aciduria) may present with a number of laboratory abnormalities.

Laboratory findings that can be seen with an organic academia:

(1) metabolic acidosis with low serum bicarbonate concentration

(2) increased anion gap

(3) lactic acidosis

(4) ketosis and ketonuria

(5) hyperammonemia

(6) hypoglycemia or hyperglycemia

(7) hyperuricemia

(8) hypertriglyceridemia

Organ Specific Damage	Laboratory Findings
liver (hepatitis)	abnormal liver function tests
pancreas (pancreatitis)	elevated serum amylase and lipase concentrations
skeletal muscle (myositis)	elevated CK and myoglobinuria
bone marrow	absolute neutropenia, anemia, thrombocytopenia

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