A patient with paroxysmal nocturnal hemoglobinuria usually falls into one of two clinical phenotypes based on laboratory features.
(2) hypoplastic (cytopenic)
(1) complete blood count (CBC)
(2) bone marrow cellularity
(3) reticulocyte count
(4) serum LDH (associated with hemolysis)
(5) percent granulocytes positive for PNH markers (clone of affected cells)
normal to moderate cytopenias
moderate to severe cytopenias
bone marrow cellularity
normal to hypercellular
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Specialty: Hematology Oncology, Clinical Laboratory