Jung et al evaluated patients with diffuse large B-cell lymphoma (DLBCL) using serum LDH and components of the Glasgow Prognostic Score (GPS). The authors are from Chonnam National University in South Korea.
Patient selection: newly diagnosed diffuse large cell lymphoma (DLBCL), treated with R-CHOP
Parameters:
(1) serum LDH in U/L
(2) serum albumin in g/dL (component of Glasgow Prognostic Score)
(3) serum CRP in mg/dL (component of Glasgow Prognostic Score)
Parameter
Finding
Points
serum LDH
<= ULN
0
> ULN
1
serum albumin
>= 3.5 g/dL
0
< 3.5 g/dL
1
serum CRP
<= 1.0 mg/dL (ULN)
0
> 1.0 mg/dL
1
score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• This is converted to the L-GPS score.
Score
L-GPS Score
3
2
1 or 2
1
0
0
L-GPS
OS at 60 months
0
89%
1
64%
2
22%
Additional prognostic factors:
(1) ECOG performance status >= 2
(2) bulky disease
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