The total levodopa equivalent dose (levodopa equivalent daily dose, LEDD) can be calculated for a patient with Parkinson's disease (PD).
Parameters:
(1) dose of regular levodopa in mg
(2) dose of continuous release levodopa in mg
(3) dose of pramipexole in mg
(4) dose of ropinirole in mg
(5) dose of pergolide in mg
(6) dose of bromocriptine in mg
(7) therapy with tolcapone
Drug |
Factor |
regular levodopa |
regular levodopa dose |
continuous release levodopa |
0.75 * (continuous release dose) |
pramipexole |
67 * (pramipexole dose) |
ropinirole |
16.67 * (ropinirole dose) |
pergolide |
100 * (pergolide dose) |
bromocriptine |
10 * (bromocriptine dose) |
therapy with tolcapone |
0.25 * ((factor for regular levodopa) + (factor for continuous release levodopa)) |
total equivalent daily dose in mg =
= SUM(all 7 factors)
Purpose: To determine the total levodopa equivalents (levodopa equivalent daily dose, LEDD) for a patient with Parkinson's disease.
Specialty: Pharmacology, clinical
Objective: dosage calculations, dosage adjustments
ICD-10: F02.3, G20, G24.1,