Description

The total levodopa equivalent dose (levodopa equivalent daily dose, LEDD) can be calculated for a patient with Parkinson's disease (PD).


Parameters:

(1) dose of regular levodopa in mg

(2) dose of continuous release levodopa in mg

(3) dose of pramipexole in mg

(4) dose of ropinirole in mg

(5) dose of pergolide in mg

(6) dose of bromocriptine in mg

(7) therapy with tolcapone

 

Drug

Factor

regular levodopa

regular levodopa dose

continuous release levodopa

0.75 * (continuous release dose)

pramipexole

67 * (pramipexole dose)

ropinirole

16.67 * (ropinirole dose)

pergolide

100 * (pergolide dose)

bromocriptine

10 * (bromocriptine dose)

therapy with tolcapone

0.25 * ((factor for regular levodopa) + (factor for continuous release levodopa))

 

total equivalent daily dose in mg =

= SUM(all 7 factors)


To read more or access our algorithms and calculators, please log in or register.