Kobayashi et al reported a prognostic index for Japanese patients with diffuse large B-cell lymphoma (DLBCL). The authors are from Kyoto Prefectural University, Japanese Red Cross Kyoto Daini Hospital and Aiseikai Yamashina Hospital in Kyoto.
Parameters:
(1) serum LDH activity (relative to upper limit of normal or ULN)
(2) ECOG performance status
(3) serum albumin in g/dL
(4) extranodal disease (bone marrow, bone, skin, lung or pleura)
Parameter
Finding
Points
serum LDH
<= ULN
0
1.01 to 3 times ULN
1
> 3 times ULN
2
ECOG
0 or 1
0
>= 2
1
serum albumin
>= 3.5 g/dL
0
< 3.5 g/dL
1
extranodal disease
absent
0
present
1
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
Score
Risk
3-Year Overall Survival
0
low
96%
1 or 2
low-intermediate
85%
3
high-intermediate
64%
4 or 5
high
33%
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