A group of three findings may be a clue to the diagnoiss of Kearns-Sayre Syndrome.

Triad for Kearns-Sayre Syndrome:

(1) external ophthalmoplegia

(2) pigmentary retinopathy

(3) cardiac conduction defect, which may present with syncope


Other findings that may be detected:

(1) heart failure from ventricular dysfunction

(2) ptosis with compensatory wrinkling of the forehead

(3) endocrine disorder (diabetes, hypothyroidism, hypoparathyroidism, other)

(4) cerebellar ataxia

(5) elevated CSF protein (> 1 g/L)

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