Description

One of the classic findings of Wilson's disease is the Kayser-Fleischer ring. However, it is neither sensitive nor specific for the disease.


 

Diagnostic features of the Kayser-Fleischer ring on a slit-lamp examination:

(1) orange, brown, bluish or gray deposits in Descemet's membrane

(2) separated from the limbus by a clear zone

 

False negative conditions for Kayser-Fleischer rings:

(1) approximately 10% of patients with a neuropsychiatric presentation

(2) up to 50% of patients with hepatic presentation

(3) often incomplete early in the course of the disease, becoming circumferential only later

 

False positive conditions with a Kayser-Fleischer-like (pseudo-Kayser Fleischer) ring:

(1) primary biliary cirrhosis

(2) autoimmune chronic active hepatitis

(3) neonatal hepatitis

 


To read more or access our algorithms and calculators, please log in or register.