Jordans' anomaly refers to the presence of lipid droplets in the cytoplasm of granulocytes.
The presence of Jordans' anomaly is a hallmark of Chanarin-Dorfman syndrome.
Features in the peripheral blood smear:
(1) presence of cytoplasmic inclusion in granulocytes
(2) the inclusions stain positive with lipid stains
Features of Chanarin-Dorfman syndrome include:
(1) lipid droplets in the cells of multiple organs (skin, liver, bone marrow, etc)
(2) ichthyosis
(3) NAFLD that can progress to cirrhosis
Differential diagnosis:
(1) possibly total parenteral nutrition
(2) fat deposits limited to a single organ (aspiration pneumonia, fat embolism)
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Specialty: Hematology Oncology
