Japanese Vasculitis Activity Score (JVAS) for MPO-ANCA Positive Microscopic Polyangiitis with Renal Involvement

Description

Koike et al reported the Japanese Vasculitis Activity Score (JVAS) for patients with MPO-ANCA positive microscopic polyangiitis with renal involvement. This can help to identify a patient with progressive disease who requires more aggressive management. The authors are from Kurume University, Yame General Hospital and Omuta City General Hospital in Fukuoka, Japan.

Patient selection: myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis

Parameters:

(1) serum creatinine in mg/dL

(2) age in years

(3) serum CRP in mg/dL

(4) pulmonary lesion

Parameter	Finding	Points
serum creatinine	< 3.0 mg/dL	0
	3.0 to 6.0	1
	>= 6.0	2
	on dialysis	3
age	< 60 years	0
	60-69 years	1
	>= 70 years	2
serum CRP	< 2.6 mg/dL	0
	2.6 to 9.9 mg/dL	1
	>= 10.0	2
pulmonary lesion	none	0
	present	2

total score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: 0

• maximum score: 9

• A score >= 5 indicates a need for more intensive therapy.

Performance:

• The area under the ROC curve is 0.78.

• A score >= 5 had a sensitivity of 83% and specificity of 61% for death.

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Japanese Vasculitis Activity Score (JVAS) for MPO-ANCA Positive Microscopic Polyangiitis with Renal Involvement

Description

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