The Japanese grade a renal cell carcinoma based on the relative size of tumor cell nuclei. This is outlined in the General Rules of Clinical and Pathologic Studies on Renal Cell Carcinoma.
Parameter: The size of the tumor cell nuclei relative to the nuclei of normal tubular cells.
The nuclei of tumor cells are
Grade
smaller than the nuclei of normal tubular cells
1
the same size as the nuclei of normal tubular cells
2
larger than the nuclei of normal tubular cells
3
where:
• The area of the nuclei would probably be the most accurate method of comparison.
Grade 3 in the Japanese classification = Grade 3 or 4 in the Fuhrman classification.
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