Dubois et al reported criteria from an international working group (IWG) for the diagnosis of Alzheimer's Disease (AD). This includes a simplified algorithm that takes into account the different categories. The authors are from multiple institutions in Europe and North America.
Features:
(1) presence of an in vivo pathophysiologic marker
(2) clinical phenotype
(3) genetic status (autosomal dominant mutation or gene)
Pathophysiologic marker - one of the following:
(1) low amyloid beta(1-42) and high T-tau or P-tau in the CSF
(2) high retention of amyloid tracer in amyloid PET
Pathophysiologic Marker
Clinical Phenotype
Genetic Status
Diagnosis
present
amnestic syndrome of the hippocampal type
NA
typical AD
present
phenotype for atypical AD
NA
atypical AD
present
none
absent
asymptomatic at risk
present
none
present
pre-symptomatic AD
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