Tranexamic acid can reduce bleeding and improve survival in patients following severe trauma.
Mechanism of action: blocks conversion of plasminogen to plasmin by blocking lysine binding sites, thereby reducing fibrinolysis
Patient selection - both of the following:
(1) Adult trauma patient at risk for severe bleeding.
(2) The drug can be administered within 3 hours of injury (decreased mortality and decreased bleeding).
(1) loading dose: intravenous infusion of 1 gram in 1 gram in 100 mL normal saline over 10 minutes
(2) slow infusion of 1 gram over 8 hours
If the drug is started from 3 to 8 hours after the trauma then mortality is reduced but the risk of bleeding is increased.
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Purpose: To administer tranexamic acid in a trauma patient.
Specialty: Hematology Oncology, Clinical Laboratory, Clinical Pharmacology, Orthopedic Surgery, Emergency Medicine
Objective: selection, dosage calculations, dosage adjustments