A patient with acute pancreatitis may develop in vivo hemolysis.


Clinical features:

(1) The patient is initially without evidence of hemolysis.

(2) The patient develops an acute pancreatitis, typically severe.

(3) The patient develops in vivo hemolysis following the onset of the pancreatitis.

(4) No other condition can explain the hemolysis.

(5) The patient may experience recurrent episodes of hemolysis with subsequent episodes of pancreatitis.


Differential diagnosis:

(1) in vitro hemolysis

(2) condition capable of causing both hemolysis and pancreatitis (heavy alcohol use, microangiopathic hemolytic anemia)

(3) pancreatitis induced by hemolysis


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