The International Society of Thrombosis and Hemostasis (ISTH) reported criteria for major bleeding, originally in non-surgical patients.
Features of a major bleed:
(1) life-threatening or fatal
(2) cause chronic sequelae
(3) consume major healthcare resources
Criteria for a major bleed - one or more of the following:
(1) bleeding with fall in hemoglobin >= 2 g/dL
(2) bleeding requiring transfusion >= 2 units of red blood cells
(3) fatal bleed
(4) bleeding into a critical organ
Critical organ bleed:
(1) intracranial
(2) intraspinal
(3) intraocular
(4) retroperitoneal
(5) intra-articular
(6) pericardial
(7) intramuscular with compartment syndrome
A major bleed may require surgical intervention.
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Specialty: Hematology Oncology
