Condoluci et al reported a prognostic score for early stage, asymptomatic chronic lymphocytic leukemia (CLL). This can help to estimate the time to therapy. The authors are from multiple institutions in Europe.
Note: This score is distinct from the International Prognostic Index for CLL (CLL-IPI).
Patient selection: early, asymptomatic CLL
Parameters:
(1) mutation status of IGHV (immunoglobulin heavy variable) gene
(2) absolute lymphocyte count in 10^9/L
(3) lymph nodes on physical exam
Parameter
Finding
Points
mutation status IGHV
mutated
0
unmutated
1
absolute lymphocyte count
<= 15 * 10^9/L
0
> 15 * 10^9/L
1
lymph nodes
unpalpable
0
palpable
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the greater the risk.
Score
Risk Group
5-Year Cumulative Risk of Treatment
0
low
8.4%
1
intermediate
28.4%
2 or 3
high
61.2%
Performance:
• The area under the ROC curve was 0.74 in the training and 0.70 in the validation cohorts
To read more or access our algorithms and calculators, please log in or register.
