Peltan et al defined acute traumatic coagulopathy based on the International Normalized Ratio (INR) based on the prothrombin time (PT). The authors are from the University of Washington and Puget Sound Blood Center in Seattle, Washington.

Patient selection: general trauma


The normal reference range for INR is usually given as 0.8 to 1.2.


The authors defined acute traumatic coagulopathy as an INR > 1.5.


This cut-off was associated with all-cause hospital mortality (odds ratio 1.9), venous thromboembolism and multi-organ failure.


The line in Figure 2 for probability of death vs INR from 1 to 7.5 can be approximated as:


probability of death =

= (0.91 * ((INR)^2)) + (2.217 * (INR)) + 3.335



• Exclusion criteria included warfarin therapy. Other conditions associated with an elevated INR would also affect the relationship between INR and traumatic coagulopathy.

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