The therapy of meliodosis can be challenging. The standard treatment involves an initial intensive intravenous therapy to control the infection followed by a prolonged oral eradication therapy to prevent relapse.
Recommended drug: ceftazidime
Dose: 50 mg/kg, maximum 2,000 mg (2 g)
Route: intravenous (IV)
Frequency: every 6 to 8 hours
Clinical Status
Duration of Therapy
standard
10 to 14 days
severe disease
28 days or more (>= 4 weeks)
Trimethoprim sulfamethoxazole may be given to patients with bone, joint, prostatic or neurologic disease.
Trimethoprim (TMP): 8 mg per kg up to 320 mg
Sulfamethoxazole (SMX): 40 mg per kg up to 1600 mg
Frequency: every 12 hours
Route: oral
where:
• The indications for TMP-SMX are the same conditions defining severe disease, except that severe disease also involves septic shock and extensive lung disease.
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