A patient who presents with thrombotic thrombocytopenic purpura (TTP) can be separated based on the underlying mechanism.
(1) immunologic, with antibody targeting von Willebrand factor cleaving protease (VWFCP) or its bindings sites
(2) quantitative deficiency in VWFCP, such as congenital TTP
normal in past, recent exposure
variable family history, past history, physiologic stressor
taking drug associated with TTP
poor response to FFP; better to plasmapheresis
small amount of FFP
responds to drug discontinuation
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Specialty: Hematology Oncology, Clinical Laboratory