Use of bovine topical thrombin can result in acquired inhibitors to Factor V and other inhibitors. These inhibitors can cause a number of problems, including clinical bleeding.
Bovine topical thrombin is most often used as a hemostatic agent in:
(1) cardiac surgery
(3) orthopedic surgery
Autoantibodies may be formed against:
(1) Factor V
(2) Factor X
(3) Factor II (thrombin)
(1) repeated use of the bovine topical thrombin
(2) amount of bovine Factor V in the preparation
(1) prolongation of the PT and PTT that does not correct with normal plasma
(2) reduced levels of factor(s) affected by the inhibitor(s)
Complications may include:
(1) clinical bleeding, which may be refractory to therapy and which may last several weeks
(2) inability to monitor low molecular weight heparin by interference with Factor Xa assays
A human recombinant thrombin (Recothrom) is available that would be an alternative hemostatic agent that should not be immunogenic.
To read more or access our algorithms and calculators, please log in or register.
Specialty: Hematology Oncology, Clinical Laboratory