An inflammatory fibroid polyp is a benign lesion that may occur in the stomach, with the first description published by Vanek in 1949. Similar lesions can be found in other parts of the GI tract.


Previously known as: eosinophilic granuloma, inflammatory pseudotumor


Location: usually in the gastric antrum


Appearance: sessile or pedunculated polyp arising in the submucosa


Clinical features:

(1) often asymptomatic

(2) can cause gastric outlet obstruction

(3) can cause colicky abdominal pain


Histologic features:

(1) spindle cell proliferation, composed of fibroblasts or myofibroblasts

(2) often vascular

(3) chronic inflammation with prominent eosinophils


Immunohistochemical stains that are frequently positive:

(1) vimentin

(2) CD34

(3) CD64

(4) bcl-2


Immunoperoxidase stains that are negative:

(1) CD117 (for gastrointestinal stromal tumor)

(2) S100 (for neurofibroma)


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