An inflammatory fibroid polyp is a benign lesion that may occur in the stomach, with the first description published by Vanek in 1949. Similar lesions can be found in other parts of the GI tract.
Previously known as: eosinophilic granuloma, inflammatory pseudotumor
Location: usually in the gastric antrum
Appearance: sessile or pedunculated polyp arising in the submucosa
(1) often asymptomatic
(2) can cause gastric outlet obstruction
(3) can cause colicky abdominal pain
(1) spindle cell proliferation, composed of fibroblasts or myofibroblasts
(2) often vascular
(3) chronic inflammation with prominent eosinophils
Immunohistochemical stains that are frequently positive:
Immunoperoxidase stains that are negative:
(1) CD117 (for gastrointestinal stromal tumor)
(2) S100 (for neurofibroma)
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