A patient should be evaluated for hypercoagulability (thrombophilia) if certain clinical findings are present.


Criteria for Evaluating a Patient for Hypercoagulability


A single episode of idiopathic venous thromboembolism, especially if the episode occurs in the absence of recent major surgery, trauma, prolonged immobilization or metastatic carcinoma.




One or more of the following:

(1) recurrent episodes of venous thromboembolism

(2) massive venous thrombosis

(3) thrombosis in an unusual site (mesenteric vein, cerebral vein, etc.)

(4) thrombosis occurring at a young age (< 50 years) without an inducing cause

(5) a family history of thromboembolism (in 1 or more first or second degree relatives)


Additional clinical findings suggestive of hypercoagulability

(1) in women, a history of unexplained fetal wastage

(2) recurrent pulmonary embolism

(3) anticoagulant failure


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