Lamy and Loughran listed criteria for when to start treating a patient with large granuloar lymphocytic leukemia (LGLL). The authors are from Pontchaillou University in Rennes (France) and Penn State Hershey Cancer Institute.


Patient selection: large granular lymphocytic leukemia (T-cell or NK-cell)


Many patients may have a chronic, indolent course. These patients may not need therapy for some time.


Indications to treat a patient with LGLL:

(1) absolute neutrophil count < 500 per µL (severe neutropenia)

(2) moderate neutropenia AND recurrent infections

(3) anemia AND (symptomatic OR transfusion dependent)

(4) active autoimmune disorder


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