Lamy and Loughran listed criteria for when to start treating a patient with large granuloar lymphocytic leukemia (LGLL). The authors are from Pontchaillou University in Rennes (France) and Penn State Hershey Cancer Institute.
Patient selection: large granular lymphocytic leukemia (T-cell or NK-cell)
Many patients may have a chronic, indolent course. These patients may not need therapy for some time.
Indications to treat a patient with LGLL:
(1) absolute neutrophil count < 500 per µL (severe neutropenia)
(2) moderate neutropenia AND recurrent infections
(3) anemia AND (symptomatic OR transfusion dependent)
(4) active autoimmune disorder
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