Paroxysmal nocturnal hemoglobinuria (PNH) may be associated with thrombosis. Hill et al listed when a patient with thrombosis should be screened for PNH. The authors are from St. Jame’s Hospital in Leeds.


Patient selection: thrombosis


Screening test to perform: flow cytometry


Indications to screen a patient with thrombosis:

(1) thrombosis otherwise unexplained

(2) young age

(3) thrombosis of an unusual site (dermal veins, cerebral veins, intra-abdominal veins)

(4) hemolysis

(5) any cytopenia


The presence of a normal serum LDH does not exclude PNH.


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