Grever et al listed indications for treating a patient with hairy cell leukemia (HCL). The authors are from multiple institutions in North America, Europe and Israel.

Patient selection: hairy cell leukemia


Indications for therapy:

(1) one or more cytopenias (see below)

(2) symptomatic splenomegaly or other organomegaly

(3) progressive lymphocytosis

(4) progressive lymphadenopathy

(5) unexplained weight loss > 10% over past 6 months

(6) excessive fatigue


Cytopenias include:

(1) hemoglobin < 11 g/dL

(2) platelet count < 100,000 per µL

(3) absolute neutrophil count < 1,000 per µL

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