Dawson and Whyte listed criteria when a patient with an elevated blood theophylline concentration should be admitted to the hospital.
Molecular weight of theophylline: 180.17 g
Patient selection: elevated serum theophylline concentration (therapeutic range 10-20 µg/mL)
Parameters:
(1) serum theophylline concentration
(2) patient factors
Serum Theophylline |
Patient Factor |
Admit? |
> 40 µg/mL |
age < 6 months |
Yes |
> 40 µg/mL |
age > 60 years |
Yes |
> 40 µg/mL |
chronic illness |
Yes |
> 40 µg/mL |
chronic poisoning |
Yes |
> 50 µg/mL |
acute poisoning |
Yes |
NA |
signs of moderate or severe theophylline toxicity |
Yes |
Specialty: Toxicology, Emergency Medicine, Critical Care