Indications:
(1) appropriate condition
(1a) neutropenia with WBC count < 500 per µL
(1a1) The neutropenia is due to myeloid hypoplasia.
(1a2) There is a reasonable chance for recovery of bone marrow function.
(1b) Some physicians include documented granulocytic dysfunction such as chronic granulomatous disease.
(2) evidence of bacterial infection
(2a) Fever for 24-48 hours, unresponsive to appropriate antibiotic therapy
(2b) Bacterial sepsis unresponsive to antibiotics or other modes of therapy
Nonindications:
(1) prophylactic administration
(2) localized infection
(3) infections due to organisms other than bacteria
Recommendations:
(1) The product should be irradiated to avoid risk of graft-versus-host reaction.
(2) Donors should be CMV-seronegative to avoid CMV infection in the recipient.
(3) The product should not be transfused through a leukocyte reduction filter.
