Recominant human parathyroid hormone (PTH) has a number of clinical uses.


Generic Name: teriparatide

Brand Name: Forteo (Eli Lilly)


Structure: amino acids 1-34


Source: rDNA


Administration: by injection


The drug is approved by the FDA for treatment of:

(1) a woman with postmenopausal osteoporosis at high risk for fracture

(2) a male with osteoporosis at high risk for fracture

(3) during sustained therapy with glucocorticoids AND high risk for fracture


The drug has also been used to treat:

(1) primary or secondary hypoparathyroidism

(2) pseudohypoparathyroidism

(3) neonatal hypocalcemia due to hypoparathyroidism (see cautions)


Contraindications and cautions for use:

(1) hypersensitivity to the drug or its excipients

(2) history of osteosarcoma

(3) risk factors for osteosarcoma (Paget's disease, radiation therapy to skeleton, presence of open epiphyses in child or adolescent)


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