Fructosamines, or ketoamines, are formed by the nonenzymatic binding of glucose to protein molecules. The level of fructosamines in diabetics reflect the level of glycemic control over the previous 2-3 weeks. This offers additional insights to that offered by glycated hemoglobin, which reflects glycemic control over the past 6-8 (some say 4-8) weeks.
Indications for testing:
(1) verify the level of glycemic control
(2) evaluate effectiveness of modifications to glucose control over the past 2-3 weeks
(3) patient with an unstable hemoglobinopathy affecting glycated hemoglobin levels
(4) management of diabetic newborn
Conditions associated with falsely low results:
(1) increased protein loss
(2) increased protein catabolic states
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