Measurement of creatinine clearance can be used to estimate the glomerular filtration rate (GFR) in a patient with chronic renal disease. Testing should be done periodically to monitor renal function and to detect any deterioration over time.

Creatinine clearance can be measured once a year in a person with stable renal function.


It can be measured more often if the patient has:

(1) GFR < 60 mL per minute per 1.73 square meters body surface area

(2) a decline in GFR >= 4 mL per min per 1.73 square meter BSA per year (which is considered a rapid decline)

(3) deterioration/progression in the disease causing the chronic renal dysfunction

(4) exposure to risk factors for an acute decline in GFR (urinary tract obstruction, volume depletion, exposure to nephrotoxic drugs)

(5) ongoing therapy to slow progression in the decline of renal function.

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