Antithrombin III levels should be measured when certain clinical findings are present.
Unexplained deep vein thrombosis or pulmonary embolus:
(1) personal history
(2) active disease
(3) family history
Presence of an underlying condition associated with acquired antithrombin III deficiency:
Possible resistance to heparin therapy:
(1) failure of aPTT or other monitoring test to prolong as expected for a given dosage regimen
(2) recurrent thrombotic event while on heparin
Situations increasing desirability of screening:
(2) possibly with oral contraceptive therapy
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Specialty: Hematology Oncology, Clinical Laboratory