Hyperbaric oxygen (HBO) therapy has been shown to be beneficial in certain critical conditions based on the evidence of clinical trials.



(1) carbon monoxide poisoning

(2) severe cyanide poisoning



(1) Clostridial myonecrosis (gas gangrene)

(2) necrotizing soft tissue infections

(3) refractory osteomyelitis

(4) intracranial abscess


Trauma and environmental injury:

(1) acute traumatic ischemia, including crush injury and the compartment syndrome

(2) severe thermal burns

(3) decompression sickness

(4) air or gas embolism

(5) severe blood loss anemia


Radiation injury:

(1) radiation-induced osteonecrosis

(2) radiation-induced skin ulcerations


Skin ulcerations and wounds:

(1) problematic pressure, ischemic or diabetic skin ulcers

(2) skin flaps or skin grafts with marginal circulation


Hyperbaric oxygen therapy has been used experimentally or in extremis for other conditions.


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