Indications for Extracorporeal Elimination of Salicylate

Extracorporeal elimination of salicylate may be indicated if certain conditions are present.

Indications for extracorporeal elimination:

(1) acute intoxication and serum level > 100 mg/dL

(2) chronic intoxication and serum level > 60 mg/dL

(3) cardiac failure

(4) renal failure

(5) intractable metabolic acidosis

(6) severe fluid imbalance

(7) seizures (poor prognostic risk factor)

Extracorporeal Technique	Use
charcoal hemoperfusion	better salicylate clearance but does not correct fluid, acid-base or electrolyte problems as well as hemodialysis
hemodialysis	corrects fluid, acid-base and electrolyte disorders
peritoneal dialysis	third choice

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