Definite indications for diagnostic testing:
(1) disseminated or recurrent infection with a normally nonpathogenic mycobacteria
(2) persistent or recurrent infection with a non-typhi species of Salmonella
(3) infection with a poorly pathogenic mycobacteria AND a family history for nontuberculous mycobacteria
(4) infection with a poorly pathogenic mycobacteria AND a family history of disseminated infection with a non-typhi strain of Salmonella
where:
• A fifth indication might be: infection with a poorly pathogenic mycobacteria AND a family history of an inherited defect in macrophage function
Possible indications for diagnostic testing:
(1) extraintestinal infection with Salmonella enterica serovar typhi or paratyphi
(2) persistent or recurrent infection with Mycobacteria tuberculosis despite adequate therapy
(3) clinical syndrome consistent with mycobacterial infection AND history of Salmonellosis
(4) clinical syndrome consistent with mycobacterial infection AND history of severe herpesvirus infection
(5) patient with atypical histiocytosis X
Differential diagnosis:
(1) drug-resistant mycobacteria
(2) noncompliance
(3) reinfection
(4) misidentification of organisms
(5) immunosuppression or immunodeficiency
