Administration of a vaccine to protect against Salmonella enterica serotype typhi is indicated under certain circumstances.


Typhoid vaccines available:

(1) oral (live attenuated strain Ty21a)

(2) parenteral (capsular Vi polysaccharide)


Indications for administration of a typhoid fever vaccine:

(1) travel to a region endemic for Salmonella enterica serotype typhi

(2) a household contact of a typhoid carrier ("Typhoid Mary")

(3) laboratory worker who has a high probability of handling Salmonella enterica isolates

(4) when the risk of epidemic spread is high (as a mass immunization program)


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