Leukocyte reduction of a blood product (leuko-reduced) should be considered if certain conditions are present. The leukoreduction may be done at the time of blood donation, during product processing or at the time of administration.


Products considered:

(1) packed red blood cells

(2) platelets


Indications for the use of a leukocyte reduced blood product:

(1) prevention of febrile, nonhemolytic transfusion reactions

(2) prevention of cytomegalovirus (CMV) and other infectious agents

(3) reduction in the risk for HLA alloimmunization

(4) prevention of post-cardiopulmonary bypass lung injury


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