Flibanserin (Addyi) may be carefully helpful in selected women with decreased sexual desire. It is only prescribed by certified physicians.


Indication for use: premenopausal woman with hypoactive sexual desire disorder (HSDD).


It is not indicated for:

(1) postmenopausal women

(2) other disorders of depressed libido in women

(3) enhancement of sexual performance



(1) use with alcohol

(2) hepatic dysfunction

(3) significant inhibition of cytochrome P450 3A4 (CYP3A4) – ketoconazole, grapefruit juice, etc

(4) poor CYP2C19 metabolizer


An agent that induces CYP3A4 causes reduced flibanserin effect.


Adverse effects may include:

(1) severe hypotension

(2) syncope

(3) central nervous system (CNS) depression

(4) digoxin toxicity if taking digoxin

(5) nausea

(6) fatigue


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