Description

Wyllie et al developed an index for predicting risk of 6-month mortality in a patient with thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome (HUS). This can help identify a patient who may benefit from more aggressive management or a novel therapy. The authors are from the University of Western Ontario and University of Ottawa in Canada.


 

Parameters:

(1) age in years at presentation

(2) hemoglobin in g/dL at presentation

(3) temperature in °C at presentation

 

Parameters

Finding

Points

age in years

<= 40 years of age

0

 

> 40 years of age

2

hemoglobin

>= 9.0 g/dL

0

 

< 9.0 g/dL

2

temperature

<= 38.5°C

0

 

> 38.5°C

2

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 6

• The higher the score the greater the mortality.

 

Total Score

6 Month Mortality

0 or 2

12 - 14%

4

31%

6

62%

 


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