Otgonsuren et al reported the Index of NASH (ION) for the diagnosis of non-alcoholic liver diseaes (NAFLD) and non-alcoholic steatohepatitis (NASH). The authors are from Inova Health System and Inova Fairfax Hospital in Falls Church, Virginia.
Parameters:
(1) waist to hip ratio
(2) serum triglyceride concentration in mg/dL
(3) serum ALT concentration in U/L
(4) HOMA-IR
(5) sex
(6) constant
Parameter
Points if Male
Points if Female
waist to hip ratio
1.33 * (ratio)
0
serum triglycerides
0.03 * (triglycerides)
0.02 * (triglycerides)
serum ALT
0.18 * (ALT)
0.24 * (ALT)
HOMA-IR
8.53 * (HOMA)
9.61 * (HOMA)
constant
-13.93
-13.99
where:
• HOMA-IR appears to be the most important parameter.
score =
= SUM(points for all of the parameters)
Interpretation:
• A score > 50 predicts histologic NASH.
• A score > 22 indicates NAFLD.
Performance:
• The area under the ROC curve is 0.77.
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