Brewin et al reported an index for identifying ineffective erythropoiesis in patients with sickling hemoglobinopathies. The authors are from King's College London.

Patient selection: sickle cell disease



(1) serum soluble transferrin receptor in nmol/L

(2) absolute reticulocyte count in 10^9/L


index of ineffective erythropoiesis = IoIE =

= (serum transferrin receptor) / (absolute reticulocyte count)



• The upper limit of normal is 0.28.

• An index > 0.28 reflects ineffective erythropoiesis.

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