Shotar et al correlated serum concentration of S100B an in-hospital mortality following rupture of a cerebral arteriovenous malformation (AVM). This can help to identify a patient who may benefit from more aggressive management. The authors are from Pitie-Salpetriere Hospital, Sorbonne-Universite, Groupe de Recherche Clinique Biofast, Univeriste Paris-Descartes and Sainte-Anne Hospital in Paris.

Patient selection: ruptured cerebral arteriovenous malformation (AVM)


Outcome: in-hospital mortality


The primary predictor of mortality was a serum S100B concentration > 0.5 µg/L during the first 48 hours after admission. The normal reference range not stated. Analysis was done on a Roche ModularE170 analyzer.


A GCS <= 8 on admission was also associated with in-hospital mortality in the multivariate analysis, but it was not significant in a validation cohort.


Additional factors on univariate analysis:

(1) serum troponin elevation

(2) intracerebral hemorrhage >= 60 mL

(3) intraventricular hemorrhage

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