A woman with Familial Mediterranean Fever (FMF) may have impaired fertility.


Factors associated with impaired fertility:

(1) amyloidosis

(2) multiple febrile episodes

(3) pelvic adhesions

(4) being untreated (not being treated with colchicine)

(5) oligomenorrhea (which may reflect ovulatory dysfunction)


A woman with impaired fertility can often achieve pregnancy with in vitro fertilization or other method.


For a woman who does become pregnant there may be an increased risk for miscarriage especially if the woman experiences frequent febrile episodes.


Differential diagnosis:

(1) male infertility

(2) polycystic ovary syndrome


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